Novel Virus-Like Particle Vaccine Encoding the Circumsporozoite Protein of Plasmodium falciparum Is Immunogenic and Induces Functional Antibody Responses in Mice

RTS,S is the leading malaria vaccine in development, but has demonstrated only moderate protective efficacy in clinical trials. RTS,S is a virus-like particle (VLP) that uses the human hepatitis B virus as scaffold to display the malaria sporozoite antigen, circumsporozoite protein (CSP). Particle f...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Kurtovic, Liriye, Wetzel, David, Reiling, Linda, Drew, Damien R., Palmer, Catherine, Kouskousis, Betty, Hanssen, Eric, Wines, Bruce D., Hogarth, P. Mark, Suckow, Manfred, Jenzelewski, Volker, Piontek, Michael, Chan, Jo-Anne, Beeson, James G.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8010251/
https://ncbi.nlm.nih.gov/pubmed/33815393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.641421
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