Bevacizumab-Induced Mitochondrial Dysfunction, Endoplasmic Reticulum Stress, and ERK Inactivation Contribute to Cardiotoxicity

The molecular mechanisms underlying the cardiotoxicity associated with bevacizumab, a first-line immunotherapeutic agent used to treat lung cancer, are not fully understood. Here, we examined intracellular signal transduction in cardiomyocytes after exposure to different doses of bevacizumab in vitr...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Li, Yue, Tian, Wei, Yue, Dongsheng, Chen, Chen, Li, Chenguang, Zhang, Zhenfa, Wang, Changli
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8009725/
https://ncbi.nlm.nih.gov/pubmed/33859777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/5548130
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