A common 1.6 mb Y-chromosomal inversion predisposes to subsequent deletions and severe spermatogenic failure in humans

Male infertility is a prevalent condition, affecting 5–10% of men. So far, few genetic factors have been described as contributors to spermatogenic failure. Here, we report the first re-sequencing study of the Y-chromosomal Azoospermia Factor c (AZFc) region, combined with gene dosage analysis of th...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Hallast, Pille, Kibena, Laura, Punab, Margus, Arciero, Elena, Rootsi, Siiri, Grigorova, Marina, Flores, Rodrigo, Jobling, Mark A, Poolamets, Olev, Pomm, Kristjan, Korrovits, Paul, Rull, Kristiina, Xue, Yali, Tyler-Smith, Chris, Laan, Maris
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Evolutionary Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8009663/
https://ncbi.nlm.nih.gov/pubmed/33781384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.65420
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