Rational Redesign of Monoamine Oxidase A into a Dehydrogenase to Probe ROS in Cardiac Aging

[Image: see text] Cardiac senescence is a typical chronic frailty condition in the elderly population, and cellular aging is often associated with oxidative stress. The mitochondrial-membrane flavoenzyme monoamine oxidase A (MAO A) catalyzes the oxidative deamination of neurotransmitters, and its ex...

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Veröffentlicht in:ACS Chem Biol
Hauptverfasser: Iacovino, Luca Giacinto, Manzella, Nicola, Resta, Jessica, Vanoni, Maria Antonietta, Rotilio, Laura, Pisani, Leonardo, Edmondson, Dale Edward, Parini, Angelo, Mattevi, Andrea, Mialet-Perez, Jeanne, Binda, Claudia
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2020
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8009472/
https://ncbi.nlm.nih.gov/pubmed/32589395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00366
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