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Adenovirus-vectored T cell vaccine for hepacivirus shows reduced effectiveness against a CD8 T cell escape variant in rats

There is an urgent need for a vaccine to prevent chronic infection by hepatitis C virus (HCV) and its many genetic variants. The first human vaccine trial, using recombinant viral vectors that stimulate pan-genotypic T cell responses against HCV non-structural proteins, failed to demonstrate efficac...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Hartlage, Alex S., Dravid, Piyush, Walker, Christopher M., Kapoor, Amit
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8009437/
https://ncbi.nlm.nih.gov/pubmed/33735321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009391
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