Study protocol of a phase 1 clinical trial establishing the safety of intrapleural administration of liposomal curcumin: curcumin as a palliative treatment for malignant pleural effusion (IPAL-MPE)

INTRODUCTION: This is a phase 1, open-label, single-centre, uncontrolled, dose-escalation study to evaluate the feasibility, tolerability and pharmacokinetic profiles of a single dose of liposomal curcumin, administered via an existing tunnelled indwelling pleural catheter (TIPC) directly to the tum...

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Vydáno v:BMJ Open
Hlavní autoři: Hocking, Ashleigh Jean, Farrall, Alexandra L, Newhouse, Sarah, Sordillo, Peter, Greco, Kim, Karapetis, Christos Stelios, Dougherty, Brendan, Klebe, Sonja
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2021
Témata:
Respiratory Medicine
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8009239/
https://ncbi.nlm.nih.gov/pubmed/33782024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2020-047075
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