Fibroblast Growth Factor 2 Modulates Hypothalamic Pituitary Axis Activity and Anxiety Behavior Through Glucocorticoid Receptors

BACKGROUND: Despite strong evidence linking fibroblast growth factor 2 (FGF2) with anxiety and depression in both rodents and humans, the molecular mechanisms linking FGF2 with anxiety are not understood. METHODS: We compare 1) mice that lack a functional Fgf2 gene (Fgf2 knockout [KO]), 2) wild-type...

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Detalhes bibliográficos
Publicado no:Biol Psychiatry
Main Authors: Salmaso, Natalina, Stevens, Hanna E., McNeill, Jessica, ElSayed, Maha, Ren, Qiuyin, Maragnoli, Maria E., Schwartz, Michael L., Tomasi, Simone, Sapolsky, Robert M., Duman, Ronald, Vaccarino, Flora M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8009045/
https://ncbi.nlm.nih.gov/pubmed/27133954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2016.02.026
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