BCG vaccination–induced emergency granulopoiesis provides rapid protection from neonatal sepsis

Death from sepsis in the neonatal period remains a serious threat for millions. Within 3 days of administration, bacille Calmette-Guérin (BCG) vaccination can reduce mortality from neonatal sepsis in human newborns, but the underlying mechanism for this rapid protection is unknown. We found that BCG...

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Publicado no:Sci Transl Med
Main Authors: Brook, Byron, Harbeson, Danny J., Shannon, Casey P., Cai, Bing, He, Daniel, Ben-Othman, Rym, Francis, Freddy, Huang, Joe, Varankovich, Natallia, Liu, Aaron, Bao, Winnie, Bjerregaard-Andersen, Morten, Schaltz-Buchholzer, Frederik, Sanca, Lilica, Golding, Christian N., Larsen, Kristina Lindberg, Levy, Ofer, Kampmann, Beate, Tan, Rusung, Charles, Adrian, Wynn, James L., Shann, Frank, Aaby, Peter, Benn, Christine S., Tebbutt, Scott J., Kollmann, Tobias R., Amenyogbe, Nelly
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8008103/
https://ncbi.nlm.nih.gov/pubmed/32376769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aax4517
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