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Intracellular prostaglandin E2 contributes to hypoxia-induced proximal tubular cell death
Proximal tubular cells (PTC) are particularly vulnerable to hypoxia-induced apoptosis, a relevant factor for kidney disease. We hypothesized here that PTC death under hypoxia is mediated by cyclo-oxygenase (COX-2)-dependent production of prostaglandin E(2) (PGE(2)), which was confirmed in human prox...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8007803/ https://ncbi.nlm.nih.gov/pubmed/33782420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-86219-w |
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