Identification of Novel Alectinib-Resistant ALK Mutation G1202K with Sensitization to Lorlatinib: A Case Report and in silico Structural Modelling

BACKGROUND: Drug resistance caused by G1202R/G1202del mutation in anaplastic lymphoma kinase (ALK) represents a great challenge in the clinic. The effect of other mutation(s) at G1202 on the available tyrosine kinase inhibitors (TKIs) in the clinic remains unknown. CASE PRESENTATION: A 50-year-old C...

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Detalhes bibliográficos
Publicado no:Onco Targets Ther
Main Authors: Yang, Ping, Cao, Ran, Bao, Hua, Wu, Xue, Yang, Lingling, Zhu, Dongqin, Zhang, Lu, Peng, Liming, Cai, Yuefei, Zhang, Weijun, Shao, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2021
Assuntos:
Case Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8007639/
https://ncbi.nlm.nih.gov/pubmed/33790576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S293901
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