Novel Human Tenascin-C Function-Blocking Camel Single Domain Nanobodies

The extracellular matrix (ECM) molecule Tenascin-C (TNC) is well-known to promote tumor progression by multiple mechanisms. However, reliable TNC detection in tissues of tumor banks remains limited. Therefore, we generated dromedary single-domain nanobodies Nb3 and Nb4 highly specific for human TNC...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Dhaouadi, Sayda, Ben Abderrazek, Rahma, Loustau, Thomas, Abou-Faycal, Chérine, Ksouri, Ayoub, Erne, William, Murdamoothoo, Devadarssen, Mörgelin, Matthias, Kungl, Andreas, Jung, Alain, Ledrappier, Sonia, Benlasfar, Zakaria, Bichet, Sandrine, Chiquet-Ehrismann, Ruth, Hendaoui, Ismaïl, Orend, Gertraud, Bouhaouala-Zahar, Balkiss
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8006918/
https://ncbi.nlm.nih.gov/pubmed/33790905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.635166
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