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Structure–activity relationships of GPX4 inhibitor warheads
Direct inhibition of GPX4 requires covalent modification of the active-site selenocysteine. While phenotypic screening has revealed that activated alkyl chlorides and masked nitrile oxides can inhibit GPX4 covalently, a systematic assessment of potential electrophilic warheads with the capacity to i...
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| Published in: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8006158/ https://ncbi.nlm.nih.gov/pubmed/32920142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2020.127538 |
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