Phosphatidylinositol 4-kinase IIIβ mediates contraction-induced GLUT4 translocation and shows its anti-diabetic action in cardiomyocytes

In the diabetic heart, long-chain fatty acid (LCFA) uptake is increased at the expense of glucose uptake. This metabolic shift ultimately leads to insulin resistance and a reduced cardiac function. Therefore, signaling kinases that mediate glucose uptake without simultaneously stimulating LCFA uptak...

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Vydáno v:Cell Mol Life Sci
Hlavní autoři: Sun, A., Simsek Papur, O., Dirkx, E., Wong, L., Sips, T., Wang, S., Strzelecka, A., Nabben, M., Glatz, J. F. C., Neumann, D., Luiken, J. J. F. P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2020
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8004495/
https://ncbi.nlm.nih.gov/pubmed/33090289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-020-03669-7
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