Population-Based Estimates of the Age-Specific Cumulative Risk of Breast Cancer for Pathogenic Variants in CHEK2: Findings from the Australian Breast Cancer Family Registry

SIMPLE SUMMARY: It is well established that women who carry pathogenic CHEK2 variants have about a 3-fold increased risk of developing breast cancer. CHEK2 is now commonly included in genetic tests for breast cancer predisposition and increasingly used to inform the clinical management of women who...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Nguyen-Dumont, Tú, Dowty, James G., Steen, Jason A., Renault, Anne-Laure, Hammet, Fleur, Mahmoodi, Maryam, Theys, Derrick, Rewse, Amanda, Tsimiklis, Helen, Winship, Ingrid M., Giles, Graham G., Milne, Roger L., Hopper, John L., Southey, Melissa C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8003064/
https://ncbi.nlm.nih.gov/pubmed/33803639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13061378
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