Stroma-Mediated Resistance to S63845 and Venetoclax through MCL-1 and BCL-2 Expression Changes Induced by miR-193b-3p and miR-21-5p Dysregulation in Multiple Myeloma

BH3-mimetics targeting anti-apoptotic proteins such as MCL-1 (S63845) or BCL-2 (venetoclax) are currently being evaluated as effective therapies for the treatment of multiple myeloma (MM). Interleukin 6, produced by mesenchymal stromal cells (MSCs), has been shown to modify the expression of anti-ap...

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Publicat a:Cells
Autors principals: Algarín, Esperanza M., Quwaider, Dalia, Campos-Laborie, Francisco J., Díaz-Tejedor, Andrea, Mogollón, Pedro, Vuelta, Elena, Martín-Sánchez, Montserrat, San-Segundo, Laura, González-Méndez, Lorena, Gutiérrez, Norma C., García-Sanz, Ramón, Paíno, Teresa, De Las Rivas, Javier, Ocio, Enrique M., Garayoa, Mercedes
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8001939/
https://ncbi.nlm.nih.gov/pubmed/33806619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10030559
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