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Modulation of a protein-folding landscape revealed by AFM-based force spectroscopy notwithstanding instrumental limitations

Single-molecule force spectroscopy is a powerful tool for studying protein folding. Over the last decade, a key question has emerged: how are changes in intrinsic biomolecular dynamics altered by attachment to μm-scale force probes via flexible linkers? Here, we studied the folding/unfolding of α(3)...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Edwards, Devin T., LeBlanc, Marc-Andre, Perkins, Thomas T.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2021
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8000363/
https://ncbi.nlm.nih.gov/pubmed/33723041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2015728118
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