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A time course transcriptomic analysis of host and injected oncogenic cells reveals new aspects of Drosophila immune defenses

Oncogenic RasV12 cells [A. Simcox et al., PLoS Genet. 4, e1000142 (2008)] injected into adult males proliferated massively after a lag period of several days, and led to the demise of the flies after 2 to 3 wk. The injection induced an early massive transcriptomic response that, unexpectedly, includ...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Chen, Di, Roychowdhury-Sinha, Arghyashree, Prakash, Pragya, Lan, Xiao, Fan, Wenmin, Goto, Akira, Hoffmann, Jules A.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8000351/
https://ncbi.nlm.nih.gov/pubmed/33737397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2100825118
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