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The aryl hydrocarbon receptor facilitates the human cytomegalovirus-mediated G1/S block to cell cycle progression

The tryptophan metabolite, kynurenine, is known to be produced at elevated levels within human cytomegalovirus (HCMV)-infected fibroblasts. Kynurenine is an endogenous aryl hydrocarbon receptor (AhR) ligand. Here we show that the AhR is activated following HCMV infection, and pharmacological inhibit...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Naseri-Nosar, Pooya, Nogalski, Maciej T., Shenk, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8000196/
https://ncbi.nlm.nih.gov/pubmed/33723080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2026336118
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