Reduced Granule Cell Proliferation and Molecular Dysregulation in the Cerebellum of Lysosomal Acid Phosphatase 2 (ACP2) Mutant Mice

Lysosomal acid phosphatase 2 (Acp2) mutant mice (naked-ataxia, nax) have a severe cerebellar cortex defect with a striking reduction in the number of granule cells. Using a combination of in vivo and in vitro immunohistochemistry, Western blotting, BrdU assays, and RT-qPCR, we show downregulation of...

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Pubblicato in:Int J Mol Sci
Autori principali: Jiao, Xiaodan, Rahimi Balaei, Maryam, Abu-El-Rub, Ejlal, Casoni, Filippo, Pezeshgi Modarres, Hassan, Dhingra, Sanjiv, Kong, Jiming, Consalez, Giacomo G., Marzban, Hassan
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7999993/
https://ncbi.nlm.nih.gov/pubmed/33804256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22062994
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