Analysis of PI3K Pathway Associated Molecules Reveals Dysregulated Innate and Adaptive Functions of B Cells in Early Diffuse Cutaneous Systemic Sclerosis

B cell activation is an early event in the development of systemic sclerosis (SSc). The classical activation of B cells downstream of the B-cell receptor (BCR) involves the phosphatidylinositol-3 kinase (PI3K) pathway that integrates the effects of multiple co-stimulatory receptors. Our analysis of...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Simon, Diána, Erdő-Bonyár, Szabina, Rapp, Judit, Balogh, Péter, Minier, Tünde, Nagy, Gabriella, Czirják, László, Berki, Tímea
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7998899/
https://ncbi.nlm.nih.gov/pubmed/33809015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22062877
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