Rapid response to the alpha-1 adrenergic agent phenylephrine in the perioperative period is impacted by genomics and ancestry

The emergence of genomic data in biobanks and health systems offers new ways to derive medically important phenotypes, including acute phenotypes occurring during inpatient clinical care. Here we study the genetic underpinnings of the rapid response to phenylephrine, an α1-adrenergic receptor agonis...

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Veröffentlicht in:Pharmacogenomics J
Hauptverfasser: Wenric, Stephane, Jeff, Janina M., Joseph, Thomas, Yee, Muh-Ching, Belbin, Gillian M., Owusu Obeng, Aniwaa, Ellis, Stephen B., Bottinger, Erwin P., Gottesman, Omri, Levin, Matthew A., Kenny, Eimear E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7997806/
https://ncbi.nlm.nih.gov/pubmed/33168928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41397-020-00194-5
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