Inhibition of Intercellular Cytosolic Traffic via Gap Junctions Reinforces Lomustine-Induced Toxicity in Glioblastoma Independent of MGMT Promoter Methylation Status

Glioblastoma is a malignant brain tumor and one of the most lethal cancers in human. Temozolomide constitutes the standard chemotherapeutic agent, but only shows limited efficacy in glioblastoma patients with unmethylated O-6-methylguanine-DNA methyltransferase (MGMT) promoter status. Recently, it h...

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Détails bibliographiques
Publié dans:Pharmaceuticals (Basel)
Auteurs principaux: Schneider, Matthias, Potthoff, Anna-Laura, Evert, Bernd O., Dicks, Marius, Ehrentraut, Denise, Dolf, Andreas, Schmidt, Elena N. C., Schäfer, Niklas, Borger, Valeri, Pietsch, Torsten, Westhoff, Mike-Andrew, Güresir, Erdem, Waha, Andreas, Vatter, Hartmut, Heiland, Dieter H., Schuss, Patrick, Herrlinger, Ulrich
Format: Artigo
Langue:Inglês
Publié: MDPI 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7997332/
https://ncbi.nlm.nih.gov/pubmed/33673490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph14030195
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