Oral Proteasomal Inhibitors Ixazomib, Oprozomib, and Delanzomib Upregulate the Function of Organic Anion Transporter 3 (OAT3): Implications in OAT3-Mediated Drug-Drug Interactions

Organic anion transporter 3 (OAT3) is mainly expressed at the basolateral membrane of kidney proximal tubules, and is involved in the renal elimination of various kinds of important drugs, potentially affecting drug efficacy or toxicity. Our laboratory previously reported that ubiquitin modification...

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Bibliographic Details
Published in:Pharmaceutics
Main Authors: Fan, Yunzhou, Liang, Zhengxuan, Zhang, Jinghui, You, Guofeng
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7997269/
https://ncbi.nlm.nih.gov/pubmed/33670955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics13030314
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