A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells

Steroid receptor coactivator 3 (SRC-3/NCoA3/AIB1), is a key regulator of gene transcription and it plays a central role in breast cancer (BC) tumorigenesis, making it a potential therapeutic target. Beyond its function as an important regulator of estrogen receptor transcriptional activity, SRC-3 al...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Commun Biol
Hlavní autoři: Gilad, Yosi, Eliaz, Yossi, Yu, Yang, Dean, Adam M., Han, San Jung, Qin, Li, O’Malley, Bert W., Lonard, David M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7994904/
https://ncbi.nlm.nih.gov/pubmed/33767353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01929-1
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky