Glycosyltransferase POMGNT1 deficiency strengthens N-cadherin-mediated cell–cell adhesion

Defects in protein O-mannosylation lead to severe congenital muscular dystrophies collectively known as α-dystroglycanopathy. A hallmark of these diseases is the loss of the O-mannose-bound matriglycan on α-dystroglycan, which reduces cell adhesion to the extracellular matrix. Mutations in protein O...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Noor, Sina Ibne, Hoffmann, Marcus, Rinis, Natalie, Bartels, Markus F., Winterhalter, Patrick R., Hoelscher, Christina, Hennig, René, Himmelreich, Nastassja, Thiel, Christian, Ruppert, Thomas, Rapp, Erdmann, Strahl, Sabine
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7994789/
https://ncbi.nlm.nih.gov/pubmed/33610554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100433
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