Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes

Osteocytes act as mechanosensors in bone; however, the underlying mechanism remains poorly understood. Here we report that deleting Kindlin-2 in osteocytes causes severe osteopenia and mechanical property defects in weight-bearing long bones, but not in non-weight-bearing calvariae. Kindlin-2 loss i...

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Bibliografske podrobnosti
izdano v:Commun Biol
Main Authors: Qin, Lei, Fu, Xuekun, Ma, Jing, Lin, Manxia, Zhang, Peijun, Wang, Yishu, Yan, Qinnan, Tao, Chu, Liu, Wen, Tang, Bin, Chen, Di, Bai, Xiaochun, Cao, Huiling, Xiao, Guozhi
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7994671/
https://ncbi.nlm.nih.gov/pubmed/33767359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01950-4
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