IL-1β mediated nanoscale surface clustering of integrin α5β1 regulates the adhesion of mesenchymal stem cells

Clinical use of human mesenchymal stem cells (hMSCs) is limited due to their rapid clearance, reducing their therapeutic efficacy. The inflammatory cytokine IL-1β activates hMSCs and is known to enhance their engraftment. Consequently, understanding the molecular mechanism of this inflammation-trigg...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Maynard, Stephanie A., Pchelintseva, Ekaterina, Zwi-Dantsis, Limor, Nagelkerke, Anika, Gopal, Sahana, Korchev, Yuri E., Shevchuk, Andrew, Stevens, Molly M.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7994456/
https://ncbi.nlm.nih.gov/pubmed/33767269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-86315-x
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