IL-1β mediated nanoscale surface clustering of integrin α5β1 regulates the adhesion of mesenchymal stem cells

Clinical use of human mesenchymal stem cells (hMSCs) is limited due to their rapid clearance, reducing their therapeutic efficacy. The inflammatory cytokine IL-1β activates hMSCs and is known to enhance their engraftment. Consequently, understanding the molecular mechanism of this inflammation-trigg...

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發表在:Sci Rep
Main Authors: Maynard, Stephanie A., Pchelintseva, Ekaterina, Zwi-Dantsis, Limor, Nagelkerke, Anika, Gopal, Sahana, Korchev, Yuri E., Shevchuk, Andrew, Stevens, Molly M.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2021
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7994456/
https://ncbi.nlm.nih.gov/pubmed/33767269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-86315-x
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