IL-1β mediated nanoscale surface clustering of integrin α5β1 regulates the adhesion of mesenchymal stem cells

Clinical use of human mesenchymal stem cells (hMSCs) is limited due to their rapid clearance, reducing their therapeutic efficacy. The inflammatory cytokine IL-1β activates hMSCs and is known to enhance their engraftment. Consequently, understanding the molecular mechanism of this inflammation-trigg...

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Udgivet i:Sci Rep
Main Authors: Maynard, Stephanie A., Pchelintseva, Ekaterina, Zwi-Dantsis, Limor, Nagelkerke, Anika, Gopal, Sahana, Korchev, Yuri E., Shevchuk, Andrew, Stevens, Molly M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7994456/
https://ncbi.nlm.nih.gov/pubmed/33767269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-86315-x
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