Met carriers of the BDNF Val66Met polymorphism show reduced Glx/NAA in the pregenual ACC in two independent cohorts

The Met allele of the Val66Met SNP of the BDNF gene (rs6265) is associated with impaired activity-dependent release of brain-derived neurotrophic factor (BDNF), resulting in reduced synaptic plasticity, impaired glutamatergic neurotransmission, and morphological changes. While previous work has demo...

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Published in:Sci Rep
Main Authors: Martens, Louise, Herrmann, Luisa, Colic, Lejla, Li, Meng, Richter, Anni, Behnisch, Gusalija, Stork, Oliver, Seidenbecher, Constanze, Schott, Björn H., Walter, Martin
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7990923/
https://ncbi.nlm.nih.gov/pubmed/33762638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-86220-3
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