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Deficiency in CCR2 increases susceptibility of mice to infection with an intracellular pathogen, Francisella tularensis LVS, but does not impair development of protective immunity

CCR2 is the major chemokine receptor that regulates appropriate trafficking of inflammatory monocytes, but the role of this chemokine receptor and its ligands during primary and secondary infection with intracellular infections remains incompletely understood. Here we used murine infection with the...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kurtz, Sherry L., De Pascalis, Roberto, Meierovics, Anda I., Elkins, Karen L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7990183/
https://ncbi.nlm.nih.gov/pubmed/33760886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0249142
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