Extracellular cGAMP is a cancer cell-produced immunotransmitter involved in radiation-induced anti-cancer immunity

2’3’-cyclic GMP-AMP (cGAMP) is an intracellular second messenger that is synthesized in response to cytosolic double-stranded DNA and activates the innate immune STING pathway. Our previous discovery of its extracellular hydrolase ENPP1 hinted at the existence of extracellular cGAMP. Here, we detect...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Nat Cancer
Main Authors: Carozza, Jacqueline A., Böhnert, Volker, Nguyen, Khanh C., Skariah, Gemini, Shaw, Kelsey E., Brown, Jenifer A., Rafat, Marjan, von Eyben, Rie, Graves, Edward E., Glenn, Jeffrey S., Smith, Mark, Li, Lingyin
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7990037/
https://ncbi.nlm.nih.gov/pubmed/33768207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s43018-020-0028-4
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki