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Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter
LAT1 (SLC7A5) is one of the representative light chain proteins of heteromeric amino acid transporters, forming a heterodimer with its heavy chain partner 4F2hc (SLC3A2). LAT1 is overexpressed in many types of tumors and mediates the transfer of drugs and hormones across the blood-brain barrier. Thu...
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| Publicado no: | Cell Discov |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Singapore
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7988154/ https://ncbi.nlm.nih.gov/pubmed/33758168 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-021-00247-4 |
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