The HDAC Inhibitor Domatinostat Promotes Cell Cycle Arrest, Induces Apoptosis and Increases Immunogenicity of Merkel Cell Carcinoma Cells

Merkel cell carcinoma (MCC) is a rare, highly aggressive skin cancer for which immune modulation by immune checkpoint inhibitors show remarkable response rates. However, primary or secondary resistance to immunotherapy prevents benefits in a significant proportion of patients. For MCC, one immune es...

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Detalhes bibliográficos
Publicado no:J Invest Dermatol
Main Authors: Song, Lina, Bretz, Anne Catherine, Gravemeyer, Jan, Spassova, Ivelina, Muminova, Shakhlo, Gambichler, Thilo, Sriram, Ashwin, Ferrone, Soldano, Becker, Jürgen C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7987731/
https://ncbi.nlm.nih.gov/pubmed/33002502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2020.08.023
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