Development of potency, breadth and resilience to viral escape mutations in SARS-CoV-2 neutralizing antibodies

Antibodies elicited in response to infection undergo somatic mutation in germinal centers that can result in higher affinity for the cognate antigen. To determine the effects of somatic mutation on the properties of SARS-CoV-2 spike receptor-binding domain (RBD)-specific antibodies, we analyzed six...

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Publicat a:bioRxiv
Autors principals: Muecksch, Frauke, Weisblum, Yiska, Barnes, Christopher O., Schmidt, Fabian, Schaefer-Babajew, Dennis, Lorenzi, Julio C C, Flyak, Andrew I, DeLaitsch, Andrew T, Huey-Tubman, Kathryn E, Hou, Shurong, Schiffer, Celia A., Gaebler, Christian, Wang, Zijun, Da Silva, Justin, Poston, Daniel, Finkin, Shlomo, Cho, Alice, Cipolla, Melissa, Oliveira, Thiago Y., Millard, Katrina G., Ramos, Victor, Gazumyan, Anna, Rutkowska, Magdalena, Caskey, Marina, Nussenzweig, Michel C., Bjorkman, Pamela J., Hatziioannou, Theodora, Bieniasz, Paul D.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7987023/
https://ncbi.nlm.nih.gov/pubmed/33758864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.03.07.434227
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