TLR4 signaling in neurons enhances calcium-permeable AMPAR currents and drives post-traumatic epileptogenesis

OBJECTIVE: Traumatic brain injury is a major risk factor for acquired epilepsies and understanding the mechanisms underlying the early pathophysiology could yield viable therapeutic targets. Growing evidence indicates a role for inflammatory signaling in modifying neuronal excitability and promoting...

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Vydáno v:Ann Neurol
Hlavní autoři: Korgaonkar, Akshata A., Li, Ying, Sekhar, Dipika, Subramanian, Deepak, Guevarra, Jenieve, Swietek, Bogumila, Pallottie, Alexandra, Singh, Sukwinder, Kella, Kruthi, Elkabes, Stella, Santhakumar, Vijayalakshmi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7986991/
https://ncbi.nlm.nih.gov/pubmed/32031699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.25698
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