Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV-2 Macrodomain

[Image: see text] The nsP3 macrodomain is a conserved protein interaction module that plays essential regulatory roles in the host immune response by recognizing and removing posttranslational ADP-ribosylation sites during SARS-CoV-2 infection. Thus targeting this protein domain may offer a therapeu...

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Bibliografske podrobnosti
izdano v:ACS Med Chem Lett
Main Authors: Ni, Xiaomin, Schröder, Martin, Olieric, Vincent, Sharpe, May E., Hernandez-Olmos, Victor, Proschak, Ewgenij, Merk, Daniel, Knapp, Stefan, Chaikuad, Apirat
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2021
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7986975/
https://ncbi.nlm.nih.gov/pubmed/33850605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00684
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