CBLB ablation with CRISPR/Cas9 enhances cytotoxicity of human placental stem cell-derived NK cells for cancer immunotherapy

BACKGROUND: Tumors often develop resistance to surveillance by endogenous immune cells, which include natural killer (NK) cells. Ex vivo activated and/or expanded NK cells demonstrate cytotoxicity against various tumor cells and are promising therapeutics for adoptive cancer immunotherapy. Genetic m...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Guo, Xuan, Mahlakõiv, Tanel, Ye, Qian, Somanchi, Srinivas, He, Shuyang, Rana, Hemlata, DiFiglia, Andrea, Gleason, Joseph, van der Touw, William, Hariri, Robert, Zhang, Xiaokui
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2021
Assuntos:
Immune Cell Therapies and Immune Cell Engineering
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7986888/
https://ncbi.nlm.nih.gov/pubmed/33741730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001975
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