3D hydrogels reveal medulloblastoma subgroup differences and identify extracellular matrix subtypes that predict patient outcome

Medulloblastoma (MB) is the most common malignant brain tumour in children and is subdivided into four subgroups: WNT, SHH, Group 3, and Group 4. These molecular subgroups differ in their metastasis patterns and related prognosis rates. Conventional 2D cell culture methods fail to recapitulate these...

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Veröffentlicht in:J Pathol
Hauptverfasser: Linke, Franziska, Aldighieri, Macha, Lourdusamy, Anbarasu, Grabowska, Anna M, Stolnik, Snow, Kerr, Ian D, Merry, Catherine LR, Coyle, Beth
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley & Sons, Ltd 2020
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Original Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7986745/
https://ncbi.nlm.nih.gov/pubmed/33206391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.5591
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