Dimer Organization of Membrane‐Associated NS5A of Hepatitis C Virus as Determined by Highly Sensitive (1)H‐Detected Solid‐State NMR

The Hepatitis C virus nonstructural protein 5A (NS5A) is a membrane‐associated protein involved in multiple steps of the viral life cycle. Direct‐acting antivirals (DAAs) targeting NS5A are a cornerstone of antiviral therapy, but the mode‐of‐action of these drugs is poorly understood. This is due to...

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Udgivet i:Angew Chem Int Ed Engl
Main Authors: Jirasko, Vlastimil, Lends, Alons, Lakomek, Nils‐Alexander, Fogeron, Marie‐Laure, Weber, Marco E., Malär, Alexander A., Penzel, Susanne, Bartenschlager, Ralf, Meier, Beat H., Böckmann, Anja
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2021
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7986703/
https://ncbi.nlm.nih.gov/pubmed/33205864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202013296
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