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Engineered Enzymes Enable Selective N‐Alkylation of Pyrazoles With Simple Haloalkanes
Selective alkylation of pyrazoles could solve a challenge in chemistry and streamline synthesis of important molecules. Here we report catalyst‐controlled pyrazole alkylation by a cyclic two‐enzyme cascade. In this enzymatic system, a promiscuous enzyme uses haloalkanes as precursors to generate non...
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| Publicat a: | Angew Chem Int Ed Engl |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
John Wiley and Sons Inc.
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7986378/ https://ncbi.nlm.nih.gov/pubmed/33300646 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202014239 |
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