Oncometabolite L‐2‐hydroxyglurate directly induces vasculogenic mimicry through PHLDB2 in renal cell carcinoma

Metabolism reprograming is a hallmark of cancer and plays an important role in tumor progression. The aberrant metabolism in renal cell carcinoma (RCC) leads to accumulation of the oncometabolite l‐2‐hydroxyglurate (L‐2HG). L‐2HG has been reported to inhibit the activity of some α‐ketoglutarate‐depe...

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Bibliographic Details
Published in:Int J Cancer
Main Authors: Wang, Huan, Wang, Liya, Zheng, Qiming, Lu, Zeyi, Chen, Yuanlei, Shen, Danyang, Xue, Dingwei, Jiang, Minxiao, Ding, Lifeng, Zhang, Jie, Wu, Haiyang, Xia, Liqun, Qian, Jun, Li, Gonghui, Lu, Jieyang
Format: Artigo
Language:Inglês
Published: John Wiley & Sons, Inc. 2021
Subjects:
Tumor Immunology and Microenvironment
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7986127/
https://ncbi.nlm.nih.gov/pubmed/33320958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.33435
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