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Interaction with Ribosomal Proteins Accompanies Stress Induction of the Anticancer Metallodrug BOLD‐100/KP1339 in the Endoplasmic Reticulum

The ruthenium‐based anticancer agent BOLD‐100/KP1339 has shown promising results in several in vitro and in vivo tumour models as well as in early clinical trials. However, its mode of action remains to be fully elucidated. Recent evidence identified stress induction in the endoplasmic reticulum (ER...

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Publicat a:Angew Chem Int Ed Engl
Autors principals: Neuditschko, Benjamin, Legin, Anton A., Baier, Dina, Schintlmeister, Arno, Reipert, Siegfried, Wagner, Michael, Keppler, Bernhard K., Berger, Walter, Meier‐Menches, Samuel M., Gerner, Christopher
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7986094/
https://ncbi.nlm.nih.gov/pubmed/33369073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202015962
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