Interaction with Ribosomal Proteins Accompanies Stress Induction of the Anticancer Metallodrug BOLD‐100/KP1339 in the Endoplasmic Reticulum

The ruthenium‐based anticancer agent BOLD‐100/KP1339 has shown promising results in several in vitro and in vivo tumour models as well as in early clinical trials. However, its mode of action remains to be fully elucidated. Recent evidence identified stress induction in the endoplasmic reticulum (ER...

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Bibliografische gegevens
Gepubliceerd in:Angew Chem Int Ed Engl
Hoofdauteurs: Neuditschko, Benjamin, Legin, Anton A., Baier, Dina, Schintlmeister, Arno, Reipert, Siegfried, Wagner, Michael, Keppler, Bernhard K., Berger, Walter, Meier‐Menches, Samuel M., Gerner, Christopher
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2021
Onderwerpen:
Communications
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7986094/
https://ncbi.nlm.nih.gov/pubmed/33369073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202015962
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