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Matrix Stiffness Modulates Patient-Derived Glioblastoma Cell Fates in Three-Dimensional Hydrogels

Cancer progression is known to be accompanied by changes in tissue stiffness. Previous studies have primarily employed immortalized cell lines and 2D hydrogel substrates, which do not recapitulate the 3D tumor niche. How matrix stiffness affects patient-derived cancer cell fate in 3D remains unclear...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Tissue Eng Part A
Hauptverfasser: Wang, Christine, Sinha, Sauradeep, Jiang, Xinyi, Murphy, Luke, Fitch, Sergio, Wilson, Christy, Grant, Gerald, Yang, Fan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc., publishers 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7984937/
https://ncbi.nlm.nih.gov/pubmed/32731804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ten.tea.2020.0110
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