A high-content AlphaScreen™ identifies E6-specific small molecule inhibitors as potential therapeutics for HPV(+) head and neck squamous cell carcinomas

The incidence of human papillomavirus-positive head and neck squamous cell carcinoma (HPV(+)-HNSCC) has increased dramatically over the past decades due to an increase in infection of the oral mucosa by HPV. The etiology of HPV(+)-HNSCC is linked to expression of the HPV oncoprotein, E6, which influ...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Chitsike, Lennox, Yuan, Chung-Hsiang, Roy, Anuradha, Boyle, Kristopher, Duerksen-Hughes, Penelope J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2021
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7984827/
https://ncbi.nlm.nih.gov/pubmed/33796223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27908
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