Role of LrrkA in the Control of Phagocytosis and Cell Motility in Dictyostelium discoideum

LrrkA is a Dictyostelium discoideum kinase with leucine-rich repeats. LrrkA stimulates Kil2 and intra-phagosomal killing of ingested bacteria in response to folate. In this study, we show that genetic inactivation of lrrkA also causes a previously unnoticed phenotype: lrrkA KO cells exhibit enhanced...

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Publicat a:Front Cell Dev Biol
Autors principals: Bodinier, Romain, Sabra, Ayman, Leiba, Jade, Marchetti, Anna, Lamrabet, Otmane, Ayadi, Imen, Filić, Vedrana, Kawata, Takefumi, Weber, Igor, Cosson, Pierre
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
Matèries:
Cell and Developmental Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7982419/
https://ncbi.nlm.nih.gov/pubmed/33763419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.629200
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