Association of CYP2B6 Genetic Variation with Efavirenz and Nevirapine Drug Resistance in HIV-1 Patients from Botswana

PURPOSE: CYP2B6 liver enzyme metabolizes the two non-nucleoside reverse transcriptase inhibitors Efavirenz (EFV) and Nevirapine (NVP) used in the antiretroviral therapy (ART) regimens for HIV-infected individuals. Polymorphisms of the CYP2B6 gene influence drug levels in plasma and possibly virologi...

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Bibliografiske detaljer
Udgivet i:Pharmgenomics Pers Med
Main Authors: Maseng, Monkgomotsi J, Tawe, Leabaneng, Thami, Prisca K, Seatla, Kaelo K, Moyo, Sikhulile, Martinelli, Axel, Kasvosve, Ishmael, Novitsky, Vladimir, Essex, Max, Russo, Gianluca, Gaseitsiwe, Simani, Paganotti, Giacomo M
Format: Artigo
Sprog:Inglês
Udgivet: Dove 2021
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7981136/
https://ncbi.nlm.nih.gov/pubmed/33758532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/PGPM.S289471
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