Clutch mechanism of chemomechanical coupling in a DNA resecting motor nuclease

Mycobacterial AdnAB is a heterodimeric helicase–nuclease that initiates homologous recombination by resecting DNA double-strand breaks (DSBs). The N-terminal motor domain of the AdnB subunit hydrolyzes ATP to drive rapid and processive 3′ to 5′ translocation of AdnAB on the tracking DNA strand. ATP...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Unciuleac, Mihaela-Carmen, Meir, Aviv, Xue, Chaoyou, Warren, Garrett M., Greene, Eric C., Shuman, Stewart
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2021
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7980473/
https://ncbi.nlm.nih.gov/pubmed/33836607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2023955118
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