A conserved Ctp1/CtIP C-terminal peptide stimulates Mre11 endonuclease activity

The Mre11-Rad50-Nbs1 complex (MRN) is important for repairing DNA double-strand breaks (DSBs) by homologous recombination (HR). The endonuclease activity of MRN is critical for resecting 5′-ended DNA strands at DSB ends, producing 3′-ended single-strand DNA, a prerequisite for HR. This endonuclease...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Zdravković, Aleksandar, Daley, James M., Dutta, Arijit, Niwa, Tatsuya, Murayama, Yasuto, Kanamaru, Shuji, Ito, Kentaro, Maki, Takahisa, Argunhan, Bilge, Takahashi, Masayuki, Tsubouchi, Hideo, Sung, Patrick, Iwasaki, Hiroshi
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2021
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7980430/
https://ncbi.nlm.nih.gov/pubmed/33836577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2016287118
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