Progesterone receptor isoform B regulates the Oxtr-Plcl2-Trpc3 pathway to suppress uterine contractility

Uterine contractile dysfunction leads to pregnancy complications such as preterm birth and labor dystocia. In humans, it is hypothesized that progesterone receptor isoform PGR-B promotes a relaxed state of the myometrium, and PGR-A facilitates uterine contraction. This hypothesis was tested in vivo...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Peavey, Mary C., Wu, San-Pin, Li, Rong, Liu, Jian, Emery, Olivia M., Wang, Tianyuan, Zhou, Lecong, Wetendorf, Margeaux, Yallampalli, Chandra, Gibbons, William E., Lydon, John P., DeMayo, Francesco J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7980420/
https://ncbi.nlm.nih.gov/pubmed/33707208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2011643118
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