Systemic DKK1 neutralization enhances human adipose‐derived stem cell mediated bone repair

Progenitor cells from adipose tissue are able to induce bone repair; however, inconsistent or unreliable efficacy has been reported across preclinical and clinical studies. Soluble inhibitory factors, such as the secreted Wnt signaling antagonists Dickkopf‐1 (DKK1), are expressed to variable degrees...

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Detalhes bibliográficos
Publicado no:Stem Cells Transl Med
Main Authors: Negri, Stefano, Wang, Yiyun, Sono, Takashi, Qin, Qizhi, Hsu, Ginny Ching‐Yun, Cherief, Masnsen, Xu, Jiajia, Lee, Seungyong, Tower, Robert J., Yu, Victoria, Piplani, Abhi, Meyers, Carolyn A., Broderick, Kristen, Lee, Min, James, Aaron W.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2020
Assuntos:
Tissue Engineering and Regenerative Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7980212/
https://ncbi.nlm.nih.gov/pubmed/33377628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sctm.20-0293
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