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In silico simulations reveal that RYR distribution affects the dynamics of calcium release in cardiac myocytes
The dyads of cardiac myocytes contain ryanodine receptors (RYRs) that generate calcium sparks upon activation. To test how geometric factors of RYR distribution contribute to the formation of calcium sparks, which cannot be addressed experimentally, we performed in silico simulations on a large set...
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| Udgivet i: | J Gen Physiol |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Rockefeller University Press
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7980188/ https://ncbi.nlm.nih.gov/pubmed/33735373 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.202012685 |
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